Endocrine Abstracts

Introduction: Thymic hyperplasia is a rare manifestation of Graves disease. In this report, we describe a female with Graves’ disease and a neck mass that was associated with thymic hyperplasia.Case report: A 28-year-old woman was referred to our division for the evaluation of palpitations. Thyroid function tests were associated with thyrotoxicosis. Thyroid receptor antibody (TRAb) was found to be 22.3 U/l (positive: >14 U/l). Sonography showed ...

The aim of this study was to compare the efficacy of treatment with insulin alone, insulin plus acarbose, insulin plus metformin or insulin plus rosiglitazone in type 2 diabetic subjects who were previously on insulin monotherapy, and to evaluate the effects of these treatments on cardiovascular risk factors including lipid profile, C-reactive protein (CRP) and fibrinogen. Sixty-six poorly controlled type 2 diabetic patients on insulin monotherapy were involved. They were rand...

The mechanism of atherosclerosis in patients with subclinical hypothyroidism (sHT), which has been partly attributed to lipid abnormalities, is still controversial. There is substantial evidence that ox-LDL plays an important role during the atherosclerosis process and paraoxonase-1 (PON-1) significantly inhibits generation of lipid peroxidation and thus plays a role in against atherosclerosis. The aim of the study was evaluate qualitative changes in lipoprotein metabolism, hs...

Pain is one of the few drawbacks of fine-needle aspiration biopsy (FNAB) in patients with nodular thyroid disease (NTD). Lidocaine/prilocaine cream, an eutectic mixture of local anesthetics (EMLA), is a frequently used topical anesthetic. Despite its well-documented efficacy for the relief of pain associated with other cutaneous procedures that involve needle insertion, the analgesic role of EMLA has not been previously reported in patients with NTD who are undergoing FNAB. Th...

Aim: Subclinical Hypothyroidism (SH) is associated with cardiovascular disorders which may include increased risk for atherosclerosis, endothelial dysfunction and myocardial dysfunction.To investigate the prevalence of left ventricular systolic and diastolic dysfunction in patients with subclinical hypothyroidism and the effect of L-thyroxin therapy on myocardial performance using conventional echocardiographic parameters.Method: The study includes 95 pa...

Tumors of thyroid gland are one of the most prevalent forms of human cancers. Despite the various molecular mechanisms, mutations or polymorphisms of p53 have a potential role in the development and/or progression of human malignancies including thyroid. A common variation in p53 that results in adenine to proline change in codon 72 has been identified as a predisposing factor for various cancers since controversial results have been reported. In this study, we investigated co...

Metformin is considered to be the first choice in the treatment of type 2 diabetes mellitus. Lactic acidosis is a rare life-threatening complication of metformin with approximately 50% overall mortality. Metformin is contraindicated in patients with factors predisposing to lactic acidosis such as impaired renal function (eGFR <30 mL/min). Herein, we present a hemodialysis patient who developed lactic acidosis after inadvertent usage of metformin.Case...

Kidney disease occurs in diabetic patients during disease course in time. Diabetes duration, co-morbid diseases, presence of retinopathy, family history of diabetic nephropathy (DN) predict kidney involvement. Although DN is the initial diagnosis in diabetics with proteinuria, other diseases like primary glomerulonephritis (GN) could be the reason of kidney involvement. DN is increasing in proportion with the increase in diabetes prevalence, and it has been predicted to contin...

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a disorder of impaired water excretion caused by inability to suppress secretion of antidiuretic hormone. The therapy of SIADH varies with severity of hyponatremia and presence or absence of symptoms. Non-peptide vasopressin receptor antagonists (vaptans) are effective at increasing sodium in euvolemic and hypervolemic states and appear safe. We aimed to evaluate the efficacy of tolvaptan in euvolemic h...

Subacute thyroiditis is a painful disease of the thyroid gland characterized with granulomatous inflammation. Adalimumab is a human monoclonal anti TNF antibody used in the treatment of several autoimmune diseases. Here we report a case of subacute thyroiditis associated with adalimumab treatment for ankylosing spondylitis. A 42 year old female patient was admitted to the hospital for fever, chills and neck pain radiating to the right ear. She was diagnosed with ankylosing spo...